InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GMNN

Summary

InnateDB Gene

IDBG-635569.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMNN

Gene Name

geminin

Synonyms

geminin

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017329

Encoded Proteins

IDBP-687406

geminin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112312:
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:32775581-32786297

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023040

ENSBTAP00000023040

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0006275	regulation of DNA replication
GO:0006461	protein complex assembly
GO:0008156	negative regulation of DNA replication
GO:0009887	organ morphogenesis
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated