Version 5.4
| Bos taurus Gene: HAMP | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-635586.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | HAMP | ||||||
| Gene Name | hepcidin precursor | ||||||
| Synonyms | hepcidin | ||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000017042 | ||||||
| Encoded Proteins |
hepcidin
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| InnateDB Annotation from Orthologs | |||||||
| Summary |
[Homo sapiens] HAMP (hepcidin), an iron regulatory hormone and antimicrobial peptide, inhibits the liver-stage infection in malarial parasitemia by arresting Plasmodium sporozoites in liver hepatocytes and prevents their development into blood-stage parasites. (Demonstrated in murine model)
[Homo sapiens] HAMP expression in LPS or TNFA-stimulated peripheral blood leukocytes is dependent on the NFkB signalling pathway.
[Homo sapiens] HAMP expression is induced by TLR2/TLR4 ligands and may regulate pro-inflammatory cytokine production through maintenance of iron homeostasis in macrophages. (Demonstrated in mice)
[Mus musculus] Hamp is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide, functioning in modulating acute inflammatory responses by mediating transcriptional changes.
[Mus musculus] Hamp (hepcidin), an iron regulatory hormone, inhibits the liver-stage infection in malarial parasitemia by arresting Plasmodium sporozoites in liver hepatocytes and prevents their development into blood-stage parasites.
[Mus musculus] Hamp expression in LPS or Tnfa-stimulated peripheral blood leukocytes is dependent on the NFkB signalling pathway. (Demonstrated in human)
[Mus musculus] Hamp expression is induced by Tlr2/Tlr4 ligands and may regulate pro-inflammatory cytokine production through maintenance of iron homeostasis in macrophages.
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| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105697:
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 18:46177091-46178535 | ||||||
| Strand | Forward strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | C5NN20 Q2NKT0 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 512301 | ||||||
| UniGene | Bt.19804 | ||||||
| RefSeq | NM_001114508 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AB445457 BC111658 DAAA02046935 | ||||||
| GenPept | AAI11659 BAH84759 | ||||||
| RNA Seq Atlas | 512301 | ||||||