InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLG

Summary

InnateDB Gene

IDBG-98749.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLG

Gene Name

plasminogen

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000122194

Encoded Proteins

IDBP-98751

plasminogen

IDBP-98753

plasminogen

IDBP-388176

plasminogen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21464960

PLG is a serum protein that interacts with B. anthracis spores and cleaves complement 3 molecules, resulting in a decrease in macrophage phagocytosis.

InnateDB Annotation from Orthologs

Summary

PMID 21464960

[Mus musculus] Plg is a serum protein that interacts with B. anthracis spores and cleaves complement 3 molecules, resulting in a decrease in macrophage phagocytosis. (Demonstrated in human)

Entrez Gene

Summary

The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:160702238-160753315

Strand

Forward strand

Band

q26

Transcripts

ENST00000297289
ENST00000366924	ENSP00000355891
ENST00000308192	ENSP00000308938
ENST00000418964	ENSP00000389424
ENST00000462918
ENST00000483038
ENST00000484367
ENST00000494325
ENST00000471691
ENST00000493435
ENST00000467466
ENST00000461414

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	45 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0019904	protein domain specific binding
GO:0034185	apolipoprotein binding

Biological Process

GO:0002576	platelet degranulation
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0010812	negative regulation of cell-substrate adhesion
GO:0022617	extracellular matrix disassembly
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0042730	fibrinolysis
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048771	tissue remodeling
GO:0051918	negative regulation of fibrinolysis
GO:0051919	positive regulation of fibrinolysis
GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031093	platelet alpha granule lumen
GO:0031232	extrinsic component of external side of plasma membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059481

View Gene Order

ENSBTAG00000001271

Not yet available

Pathways

NETPATH

REACTOME

REACT_641

Dissolution of Fibrin Clot pathway

REACT_318

Platelet degranulation pathway

REACT_1280

Response to elevated platelet cytosolic Ca2+ pathway

REACT_16888

Signaling by PDGF pathway

REACT_15428

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_111102

Signal Transduction pathway

REACT_267716

Orphan transporters pathway

REACT_17015

Metabolism of proteins pathway

REACT_604

Hemostasis pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04610

Complement and coagulation cascades pathway

hsa05150

Staphylococcus aureus infection pathway

INOH

PID NCI

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

p75ntrpathway

p75(NTR)-mediated signaling

angiopoietinreceptor_pathway

Angiopoietin receptor Tie2-mediated signaling

syndecan_4_pathway

Syndecan-4-mediated signaling events

amb2_neutrophils_pathway

amb2 Integrin signaling

Cross-References

SwissProt

P00747

TrEMBL

B4DPH4 Q5TEH5 Q68DS2 Q9UMI2

UniProt Splice Variant

Entrez Gene

5340

UniGene

Hs.143436

RefSeq

NM_000301 NM_001168338

HUGO

HGNC:9071

OMIM

173350

CCDS

CCDS5279 CCDS55074

HPRD

01417

IMGT

EMBL

AK298338 AL109933 AY192161 BC060513 CH471051 CR749293 K02921 K02922 M33272 M33274 M33275 M33278 M33279 M33280 M33282 M33283 M33284 M33285 M33286 M33287 M33288 M33289 M33290 M34272 M34273 M34275 M34276 M74220 X05199

GenPept

AAA36451 AAA60113 AAA60123 AAA60124 AAH60513 AAN85555 BAG60586 CAA28831 CAH18148 CAI22908 EAW47592

RNA Seq Atlas

5340