Version 5.4
Bos taurus Gene: AKR1B1
Summary
InnateDB Gene IDBG-635622.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKR1B1
Gene Name aldose reductase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009902
Encoded Proteins
IDBP-687470
aldose reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085662:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99016785-99033590
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013082 ENSBTAP00000013082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000085662
View Gene Order
ENSMUSG00000001642
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11038
Pregnenolone biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_223561
Pregnenolone biosynthesis pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00051
Fructose and mannose metabolism pathway
hsa00561
Glycerolipid metabolism pathway
mmu00051
Fructose and mannose metabolism pathway
mmu00040
Pentose and glucuronate interconversions pathway
mmu00052
Galactose metabolism pathway
mmu00561
Glycerolipid metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL Q5E962 Q862S5
UniProt Splice Variant
Entrez Gene 317748
UniGene Bt.11899 Bt.63116 Bt.65047 Bt.90407
RefSeq NM_001012519
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB098903 BC110178 BT021058 DAAA02011619
GenPept AAI10179 AAX09075 BAC56393
RNA Seq Atlas 317748

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca