InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GPLD1

Summary

InnateDB Gene

IDBG-635633.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPLD1

Gene Name

phosphatidylinositol-glycan-specific phospholipase D precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004982

Encoded Proteins

IDBP-687494

phosphatidylinositol-glycan-specific phospholipase D

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112293:
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:32984456-33036038

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006557

ENSBTAP00000006557

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004621	glycosylphosphatidylinositol phospholipase D activity
GO:0004630	phospholipase D activity
GO:0005515	protein binding

Biological Process

GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002430	complement receptor mediated signaling pathway
GO:0006507	GPI anchor release
GO:0008285	negative regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0009749	response to glucose
GO:0010595	positive regulation of endothelial cell migration
GO:0032869	cellular response to insulin stimulus
GO:0035690	cellular response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045919	positive regulation of cytolysis
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0071277	cellular response to calcium ion
GO:0071397	cellular response to cholesterol
GO:0071401	cellular response to triglyceride
GO:0071467	cellular response to pH
GO:1900076	regulation of cellular response to insulin stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005765	lysosomal membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000112293

View Gene Order

ENSMUSG00000021340

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00563

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway

mmu00563

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway

INOH

PID NCI

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.452

RefSeq

NM_174816 XM_005223736 XM_005223737 XM_005223738

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas