Version 5.4
Mus musculus Gene: Gpld1
Summary
InnateDB Gene IDBG-139370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpld1
Gene Name glycosylphosphatidylinositol specific phospholipase D1
Synonyms 6330541J12Rik; AW546131
Species Mus musculus
Ensembl Gene ENSMUSG00000021340
Encoded Proteins
IDBP-139372
glycosylphosphatidylinositol specific phospholipase D1
IDBP-532179
glycosylphosphatidylinositol specific phospholipase D1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112293:
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:24943152-24990753
Strand Forward strand
Band A3.1
Transcripts
ENSMUST00000021773 ENSMUSP00000021773
ENSMUST00000128315
ENSMUST00000143010 ENSMUSP00000120943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004621 glycosylphosphatidylinositol phospholipase D activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
Biological Process
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002430 complement receptor mediated signaling pathway
GO:0006507 GPI anchor release
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010595 positive regulation of endothelial cell migration
GO:0032869 cellular response to insulin stimulus
GO:0035690 cellular response to drug
GO:0043065 positive regulation of apoptotic process
GO:0045919 positive regulation of cytolysis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0071277 cellular response to calcium ion
GO:0071397 cellular response to cholesterol
GO:0071401 cellular response to triglyceride
GO:0071467 cellular response to pH
GO:1900076 regulation of cellular response to insulin stimulus
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112293
View Gene Order
ENSBTAG00000004982
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.291831
RefSeq NM_008156
OMIM
CCDS CCDS26384
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca