Version 5.4
Bos taurus Gene: BT.26972
Summary
InnateDB Gene IDBG-635764.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.26972
Gene Name CCR4-NOT transcription complex subunit 4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017919
Encoded Proteins
IDBP-687640
CCR4-NOT transcription complex subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22159038
[Homo sapiens] CNOT4 enhances JAK/STAT pathway-dependent gene expression by positively regulating IFN-gamma- and IL4-induced STAT-mediated gene responses.
PMID 22159038
[Mus musculus] Cnot4 enhances JAK/STAT pathway-dependent gene expression by positively regulating IFN-gamma- and IL4-induced STAT-mediated gene responses. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080802:
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99983487-100133488
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023825 ENSBTAP00000023825
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0051865 protein autoubiquitination
Cellular Component
GO:0030014 CCR4-NOT complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000080802
View Gene Order
ENSMUSG00000038784
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
REACT_244119
Deadenylation of mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MWA7
UniProt Splice Variant
Entrez Gene 540891
UniGene Bt.26972
RefSeq NM_001035432 XM_005205772
HUGO HGNC:7880
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02011636 DAAA02011637 DAAA02011638 DAAA02011639
GenPept
RNA Seq Atlas 540891

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca