Version 5.4
Bos taurus Gene: ELA2A
Summary
InnateDB Gene IDBG-635875.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELA2A
Gene Name chymotrypsin-like elastase family member 2A precursor
Synonyms Ela2; ELA2A
Species Bos taurus
Ensembl Gene ENSBTAG00000024496
Encoded Proteins
IDBP-687751
chymotrypsin-like elastase family member 2A precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142615:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:53272046-53288451
Strand Reverse strand
Band
Transcripts
ENSBTAT00000034039 ENSBTAP00000033941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0017171 serine hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0061436 establishment of skin barrier
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000142615
View Gene Order
ENSMUSG00000058579
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04972
Pancreatic secretion pathway
hsa04974
Protein digestion and absorption pathway
mmu04974
Protein digestion and absorption pathway
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.311
RefSeq NM_174714
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca