Version 5.4
Bos taurus Gene: FXR1
Summary
InnateDB Gene IDBG-635881.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXR1
Gene Name fragile X mental retardation syndrome-related protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016457
Encoded Proteins
IDBP-687760
fragile X mental retardation syndrome-related protein 1
IDBP-687762
fragile X mental retardation syndrome-related protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19864602
[Homo sapiens] FXR1 is an essential component of a network of nuclear receptors that regulate intestinal innate immunity and homeostasis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114416:
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86678925-86751963
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021880 ENSBTAP00000021880
ENSBTAT00000016666 ENSBTAP00000016666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002151 G-quadruplex RNA binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007517 muscle organ development
GO:0017148 negative regulation of translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0016020 membrane
GO:0043034 costamere
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114416
View Gene Order
ENSMUSG00000027680
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6QLG6 F1N4M9
UniProt Splice Variant
Entrez Gene 536793
UniGene Bt.26482
RefSeq NM_001038562 XM_005201604
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC147957 DAAA02001936 DAAA02001937
GenPept AAI47958
RNA Seq Atlas 536793

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca