InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.92088

Summary

InnateDB Gene

IDBG-636059.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.92088

Gene Name

ubiquilin-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014827

Encoded Proteins

IDBP-687953

ubiquilin-1

IDBP-687954

ubiquilin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21695056

[Homo sapiens] UBQLN1 strongly suppresses the transcriptional activation of the IFNB promoter and is an inhibitor of the TLR3/TICAM1 anti-viral pathway by reducing TICAM1 protein levels.

PMID 21695056

[Mus musculus] Ubqln1 strongly suppresses the transcriptional activation of Ifnb promoter and is an inhibitor of the Tlr3/Ticam1 anti-viral pathway by reducing Ticam1 protein levels. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135018:
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:78223447-78279808

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033922	ENSBTAP00000033825
ENSBTAT00000019747	ENSBTAP00000019747

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019900	kinase binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0031396	regulation of protein ubiquitination
GO:0034976	response to endoplasmic reticulum stress
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0071456	cellular response to hypoxia
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000135018

View Gene Order

ENSMUSG00000005312

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04141

Protein processing in endoplasmic reticulum pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

cxcr4_pathway

CXCR4-mediated signaling events

Cross-References

SwissProt

TrEMBL

F1N1A3 Q95M59

UniProt Splice Variant

Entrez Gene

282392

UniGene

Bt.92088

RefSeq

NM_174628 XM_005210304

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY035552 DAAA02023899 DAAA02023900

GenPept

AAK61367

RNA Seq Atlas

282392