Version 5.4
Bos taurus Gene: BT.101937
Summary
InnateDB Gene IDBG-636315.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.101937
Gene Name serine/threonine-protein phosphatase PP1-beta catalytic subunit
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012447
Encoded Proteins
IDBP-688233
serine/threonine-protein phosphatase PP1-beta catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213639:
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70961032-70997556
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016514 ENSBTAP00000016514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0050115 myosin-light-chain-phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0030155 regulation of cell adhesion
GO:0032922 circadian regulation of gene expression
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0070688 MLL5-L complex
GO:0072357 PTW/PP1 phosphatase complex
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000014956
View Gene Order
ENSG00000213639
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_245618
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_215733
Downregulation of TGF-beta receptor signaling pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_203510
TGF-beta receptor signaling activates SMADs pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_494
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_2203
G2/M Transition pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_111217
Metabolism pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
mmu04910
Insulin signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04720
Long-term potentiation pathway
mmu04510
Focal adhesion pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04114
Oocyte meiosis pathway
mmu03015
mRNA surveillance pathway pathway
hsa04810
Regulation of actin cytoskeleton pathway
hsa04720
Long-term potentiation pathway
hsa04910
Insulin signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04114
Oocyte meiosis pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL F1MW57
UniProt Splice Variant
Entrez Gene 538829
UniGene Bt.101937 Bt.5600
RefSeq NM_001034653
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031572 DAAA02031573 DAAA02031574 DAAA02031575
GenPept
RNA Seq Atlas 538829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca