InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPAS2

Summary

InnateDB Gene

IDBG-63633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPAS2

Gene Name

neuronal PAS domain protein 2

Synonyms

bHLHe9; MOP4; PASD4

Species

Homo sapiens

Ensembl Gene

ENSG00000170485

Encoded Proteins

IDBP-63635

neuronal PAS domain protein 2

IDBP-383666

neuronal PAS domain protein 2

IDBP-383667

neuronal PAS domain protein 2

IDBP-383670

neuronal PAS domain protein 2

IDBP-383674

neuronal PAS domain protein 2

IDBP-383675

neuronal PAS domain protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:100820152-100996829

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000335681	ENSP00000338283
ENST00000427413	ENSP00000397595
ENST00000448812	ENSP00000388528
ENST00000451740	ENSP00000395265
ENST00000450763	ENSP00000392125
ENST00000433408	ENSP00000393396
ENST00000486017
ENST00000492373
ENST00000474550
ENST00000471974
ENST00000495559
ENST00000490052

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity
GO:0051879	Hsp90 protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0032922	circadian regulation of gene expression
GO:0042745	circadian sleep/wake cycle
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045475	locomotor rhythm
GO:0045739	positive regulation of DNA repair
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051775	response to redox state
GO:0060548	negative regulation of cell death
GO:2001020	regulation of response to DNA damage stimulus