Bos taurus Gene: PAK7 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-636418.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PAK7 | ||||||||||||||||||
Gene Name | serine/threonine-protein kinase PAK 7 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||
Ensembl Gene | ENSBTAG00000017679 | ||||||||||||||||||
Encoded Proteins |
p21 protein (Cdc42/Rac)-activated kinase 7
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101349:
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 13:2474411-2518380 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | |||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Activation of Rac pathway
Signaling by Robo receptor pathway
Developmental Biology pathway
Axon guidance pathway
Signaling by Robo receptor pathway
Axon guidance pathway
Developmental Biology pathway
Activation of Rac pathway
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KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Axon guidance pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | F1MY55 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 513432 | ||||||||||||||||||
UniGene | Bt.112019 Bt.39843 | ||||||||||||||||||
RefSeq | NM_001206594 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | DAAA02035027 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 513432 | ||||||||||||||||||