Bos taurus Gene: MECOM | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-636773.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | MECOM | ||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||
Synonyms | EVI1 | ||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000005871 | ||||||||||||||
Encoded Proteins |
MDS1 and EVI1 complex locus
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085276:
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 1:99090972-99143289 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME | |||||||||||||||
KEGG |
MAPK signaling pathway pathway
Chronic myeloid leukemia pathway
Pathways in cancer pathway
MAPK signaling pathway pathway
Chronic myeloid leukemia pathway
Pathways in cancer pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | E1BMZ2 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 532209 | ||||||||||||||
UniGene | Bt.105660 Bt.106181 | ||||||||||||||
RefSeq | XM_003581740 XM_003581741 XM_003585683 XM_003585684 XM_005195927 XM_005195928 XM_005195931 XM_005195933 XM_005195934 XM_005201766 XM_005201767 XM_005201770 XM_005201772 XM_005201773 | ||||||||||||||
HUGO | HGNC:3498 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | DAAA02002232 | ||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | 532209 | ||||||||||||||