Version 5.4
Homo sapiens Gene: MECOM
Summary
InnateDB Gene IDBG-64075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MECOM
Gene Name MDS1 and EVI1 complex locus
Synonyms AML1-EVI-1; EVI1; MDS1; MDS1-EVI1; PRDM3
Species Homo sapiens
Ensembl Gene ENSG00000085276
Encoded Proteins
IDBP-64079
MDS1 and EVI1 complex locus
IDBP-385233
MDS1 and EVI1 complex locus
IDBP-483570
MDS1 and EVI1 complex locus
IDBP-474194
MDS1 and EVI1 complex locus
IDBP-478080
MDS1 and EVI1 complex locus
IDBP-479164
MDS1 and EVI1 complex locus
IDBP-481505
MDS1 and EVI1 complex locus
IDBP-479328
MDS1 and EVI1 complex locus
IDBP-479094
MDS1 and EVI1 complex locus
IDBP-478192
MDS1 and EVI1 complex locus
IDBP-483563
MDS1 and EVI1 complex locus
IDBP-483003
MDS1 and EVI1 complex locus
IDBP-473980
MDS1 and EVI1 complex locus
IDBP-475421
MDS1 and EVI1 complex locus
IDBP-484915
MDS1 and EVI1 complex locus
IDBP-480263
MDS1 and EVI1 complex locus
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:169083499-169663618
Strand Reverse strand
Band q26.2
Transcripts
ENST00000264674 ENSP00000264674
ENST00000433243 ENSP00000394302
ENST00000464456 ENSP00000419770
ENST00000472280 ENSP00000420048
ENST00000494292 ENSP00000417899
ENST00000468789 ENSP00000419995
ENST00000460814 ENSP00000420466
ENST00000492586 ENSP00000417506
ENST00000461430
ENST00000484519 ENSP00000417299
ENST00000460890 ENSP00000417922
ENST00000487503 ENSP00000419757
ENST00000494597 ENSP00000420072
ENST00000475754 ENSP00000418828
ENST00000481315 ENSP00000418046
ENST00000466623 ENSP00000418689
ENST00000485957
ENST00000486748 ENSP00000419537
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 63 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0030154 cell differentiation
GO:0043069 negative regulation of programmed cell death
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046329 negative regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:0071425 hematopoietic stem cell proliferation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027684
View Gene Order
ENSBTAG00000005871
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JU02
UniProt Splice Variant
Entrez Gene 2122
UniGene Hs.165830 Hs.611391 Hs.656395 Hs.743856
RefSeq NM_001105077 NM_001105078 NM_001163999 NM_001164000 NM_001205194 NM_004991 NM_005241 XM_005247213 XM_005247216 XM_005247219 XM_005247220 XM_005247221 XM_005247223 XM_006713536
HUGO HGNC:3498
OMIM 165215
CCDS CCDS3205 CCDS54669 CCDS54670
HPRD 01310
IMGT
EMBL AC007849 AC024099 AC069220 AC074033 AC078985
GenPept
RNA Seq Atlas 2122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca