InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SERPINB9

Summary

InnateDB Gene

IDBG-636797.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINB9

Gene Name

serpin B9

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000031267

Encoded Proteins

IDBP-688766

serpin B9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22167597

[Homo sapiens] SERPINB9 expression in human tubular epithelial cells (TECs) is induced by triggering of the viral double-stranded RNA sensors TLR3, IFIH1 and DDX58. SERPINB9 upregulation increases the threshold for granzyme B-mediated apoptosis in TECs and protects the kidney against cytotoxic insults during viral infection.

PMID 22167597

[Mus musculus] Serpinb9 expression in tubular epithelial cells (TECs) is induced by triggering of the viral double-stranded RNA sensors Tlr3, Ifih1 and Ddx58. Serpinb9 upregulation increases the threshold for granzyme B-mediated apoptosis in TECs and protects the kidney against cytotoxic insults during viral infection. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170542:
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:50636583-50645574

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024445

ENSBTAP00000024445

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0002448	mast cell mediated immunity
GO:0006955	immune response
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071391	cellular response to estrogen stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000170542

View Gene Order

ENSMUSG00000045827

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05146

Amoebiasis pathway

mmu05146

Amoebiasis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.19244

RefSeq

NM_001075859 XM_005223867

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas