Version 5.4
Bos taurus Gene: WNK2
Summary
InnateDB Gene IDBG-636864.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNK2
Gene Name Uncharacterized protein; WNK2 protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008301
Encoded Proteins
IDBP-688872
Uncharacterized proteinWNK2 protein
IDBP-688876
Uncharacterized proteinWNK2 protein
IDBP-688885
Uncharacterized proteinWNK2 protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165238:
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:85984692-86130645
Strand Forward strand
Band
Transcripts
ENSBTAT00000065526 ENSBTAP00000054423
ENSBTAT00000060961 ENSBTAP00000053530
ENSBTAT00000010935 ENSBTAP00000010935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0046777 protein autophosphorylation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:2000021 regulation of ion homeostasis
GO:2000651 positive regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165238
View Gene Order
ENSMUSG00000037989
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3MXZ8
UniProt Splice Variant
Entrez Gene 506520
UniGene Bt.110178 Bt.110795 Bt.21050
RefSeq XM_002689849 XM_005199273 XM_005199274 XM_005199275 XM_005199276 XM_005199278 XM_005210446 XM_005210447 XM_005210448 XM_005210449 XM_005210451 XM_582977
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02024062 DAAA02024063
GenPept
RNA Seq Atlas 506520

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca