InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNK2

Summary

InnateDB Gene

IDBG-76524.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNK2

Gene Name

WNK lysine deficient protein kinase 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000165238

Encoded Proteins

IDBP-76534

WNK lysine deficient protein kinase 2

IDBP-239451

WNK lysine deficient protein kinase 2

IDBP-375396

WNK lysine deficient protein kinase 2

IDBP-375434

WNK lysine deficient protein kinase 2

IDBP-375438

WNK lysine deficient protein kinase 2

IDBP-375441

WNK lysine deficient protein kinase 2

IDBP-375445

WNK lysine deficient protein kinase 2

IDBP-375448

WNK lysine deficient protein kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:93184916-93320572

Strand

Forward strand

Band

q22.31

Transcripts

ENST00000297954	ENSP00000297954
ENST00000395477	ENSP00000378860
ENST00000448039	ENSP00000412465
ENST00000427277	ENSP00000411181
ENST00000432730	ENSP00000415038
ENST00000411624	ENSP00000414622
ENST00000448251	ENSP00000390441
ENST00000453718	ENSP00000413325
ENST00000464625
ENST00000478583
ENST00000462595
ENST00000474009
ENST00000479696
ENST00000467401
ENST00000460335
ENST00000471076

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:2000021	regulation of ion homeostasis
GO:2000651	positive regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037989

View Gene Order

ENSBTAG00000008301

Not yet available

Pathways

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.654856

RefSeq

NM_001282394 NM_006648 XM_005252137 XM_005252138 XM_005252140 XM_005252141 XM_005252144 XM_006717240

HUGO

OMIM

CCDS

CCDS75858

HPRD

06951

IMGT

EMBL

GenPept

RNA Seq Atlas