Version 5.4
Bos taurus Gene: SYP
Summary
InnateDB Gene IDBG-637123.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYP
Gene Name synaptophysin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016096
Encoded Proteins
IDBP-689116
synaptophysin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 7559603
[Homo sapiens] SYP is a protein tyrosine phosphatase that associates with IL6ST and JAK2 in IL-11 signal transduction pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102003:
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:92308616-92320415
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021428 ENSBTAP00000021428
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0015485 cholesterol binding
GO:0042169 SH2 domain binding
GO:0042802 identical protein binding
GO:0051020 GTPase binding
Biological Process
GO:0006810 transport
GO:0045920 negative regulation of exocytosis
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0071310 cellular response to organic substance
Cellular Component
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030136 clathrin-coated vesicle
GO:0030285 integral component of synaptic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0042584 chromaffin granule membrane
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0044306 neuron projection terminus
GO:0045202 synapse
GO:0048786 presynaptic active zone
GO:0060076 excitatory synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000102003
View Gene Order
ENSMUSG00000031144
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.674
RefSeq NM_173963
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca