Version 5.4
Bos taurus Gene: POMC
Summary
InnateDB Gene IDBG-637211.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POMC
Gene Name Pro-opiomelanocortin NPP Melanotropin gamma Corticotropin Melanotropin alpha Corticotropin-like intermediary peptide Lipotropin beta Lipotropin gamma Melanotropin beta Beta-endorphin Met-enkephalin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007897
Encoded Proteins
IDBP-689205
Pro-opiomelanocortinNPPMelanotropin gammaCorticotropinMelanotropin alphaCorticotropin-like intermediary peptideLipotropin betaLipotropin gammaMelanotropin betaBeta-endorphinMet-enkephalin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115138:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74109410-74116893
Strand Forward strand
Band
Transcripts
ENSBTAT00000010386 ENSBTAP00000010386
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
GO:0070996 type 1 melanocortin receptor binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0008217 regulation of blood pressure
GO:0032098 regulation of appetite
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033059 cellular pigmentation
GO:0042593 glucose homeostasis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070873 regulation of glycogen metabolic process
GO:2000852 regulation of corticosterone secretion
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005782 peroxisomal matrix
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115138
View Gene Order
ENSMUSG00000020660
View Gene Order
Pathways
NETPATH
REACTOME
REACT_210701
Peptide hormone metabolism pathway
REACT_209020
Endogenous sterols pathway
REACT_222419
G-protein activation pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_205369
Signaling by GPCR pathway
REACT_206547
G alpha (s) signalling events pathway
REACT_226409
Phase 1 - Functionalization of compounds pathway
REACT_227682
Glucocorticoid biosynthesis pathway
REACT_218176
Biological oxidations pathway
REACT_210568
G alpha (i) signalling events pathway
REACT_214353
Signal Transduction pathway
REACT_220432
Peptide hormone biosynthesis pathway
REACT_213782
Metabolism of proteins pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208375
Metabolism of steroid hormones and vitamin D pathway
REACT_219139
Metabolism pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_219672
Opioid Signalling pathway
REACT_219110
Cytochrome P450 - arranged by substrate type pathway
REACT_212422
Androgen biosynthesis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_15452
Peptide hormone biosynthesis pathway
REACT_11036
Glucocorticoid biosynthesis pathway
REACT_11059
Androgen biosynthesis pathway
REACT_13812
Endogenous sterols pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_14797
Signaling by GPCR pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_17015
Metabolism of proteins pathway
REACT_21340
GPCR ligand binding pathway
REACT_111217
Metabolism pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_232159
Cytochrome P450 - arranged by substrate type pathway
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_207160
Glucocorticoid biosynthesis pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188937
Metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_227038
Endogenous sterols pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_205726
G-protein activation pathway
REACT_231468
GPCR ligand binding pathway
REACT_220332
Androgen biosynthesis pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_232343
Biological oxidations pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
REACT_242718
Peptide hormone biosynthesis pathway
KEGG
hsa04920
Adipocytokine signaling pathway pathway
hsa04916
Melanogenesis pathway
mmu04916
Melanogenesis pathway
mmu04920
Adipocytokine signaling pathway pathway
INOH
INOH website
GPCR signaling pathway
INOH website
GPCR signaling pathway
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
syndecan_3_pathway
Syndecan-3-mediated signaling events
Cross-References
SwissProt P01190
TrEMBL D8UZ68 Q9TRK0
UniProt Splice Variant
Entrez Gene 281416
UniGene Bt.8797
RefSeq NM_174151 XM_005212920
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122728 GQ280285 J00019 J00021 M10723 M23814 M25587 V00107
GenPept AAA30354 AAA30414 AAA30718 AAB59262 AAI22729 ADG57599 CAA23440 CAA23441
RNA Seq Atlas 281416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca