InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: APOB

Summary

InnateDB Gene

IDBG-637535.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOB

Gene Name

Uncharacterized protein

Synonyms

APOB-100; ApoB(100)

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008505

Encoded Proteins

IDBP-689595

apolipoprotein B (including Ag(x) antigen)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084674:
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:77953380-78040118

Strand

Forward strand

Band

Transcripts

ENSBTAT00000038995

ENSBTAP00000038799

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008201	heparin binding
GO:0017127	cholesterol transporter activity
GO:0035473	lipase binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006629	lipid metabolic process
GO:0006642	triglyceride mobilization
GO:0006869	lipid transport
GO:0007283	spermatogenesis
GO:0007399	nervous system development
GO:0008203	cholesterol metabolic process
GO:0009566	fertilization
GO:0009615	response to virus
GO:0009791	post-embryonic development
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010884	positive regulation of lipid storage
GO:0010886	positive regulation of cholesterol storage
GO:0016042	lipid catabolic process
GO:0019433	triglyceride catabolic process
GO:0030301	cholesterol transport
GO:0030317	sperm motility
GO:0033344	cholesterol efflux
GO:0034374	low-density lipoprotein particle remodeling
GO:0034383	low-density lipoprotein particle clearance
GO:0035023	regulation of Rho protein signal transduction
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042159	lipoprotein catabolic process
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0045540	regulation of cholesterol biosynthetic process
GO:0048844	artery morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0034359	mature chylomicron
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0042627	chylomicron