Version 5.4
Bos taurus Gene: PTGFR
Summary
InnateDB Gene IDBG-637588.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTGFR
Gene Name Prostaglandin F2-alpha receptor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015902
Encoded Proteins
IDBP-689607
prostaglandin F2-alpha receptor
IDBP-689610
prostaglandin F2-alpha receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122420:
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:66382018-66445670
Strand Reverse strand
Band
Transcripts
ENSBTAT00000043774 ENSBTAP00000041319
ENSBTAT00000043776 ENSBTAP00000041321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004955 prostaglandin receptor activity
GO:0004958 prostaglandin F receptor activity
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000122420
View Gene Order
ENSMUSG00000028036
View Gene Order
Pathways
NETPATH
REACTOME
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_205369
Signaling by GPCR pathway
REACT_213855
Eicosanoid ligand-binding receptors pathway
REACT_214353
Signal Transduction pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_217614
Prostanoid ligand receptors pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18425
Prostanoid ligand receptors pathway
REACT_18352
Eicosanoid ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
REACT_223625
GPCR downstream signaling pathway
REACT_230556
Prostanoid ligand receptors pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_231468
GPCR ligand binding pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_188257
Signal Transduction pathway
REACT_253164
Eicosanoid ligand-binding receptors pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P37289
TrEMBL
UniProt Splice Variant
Entrez Gene 282020
UniGene Bt.352
RefSeq NM_181025 XM_005204371 XM_005204372
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL D17395 D89039
GenPept BAA04218 BAA20871
RNA Seq Atlas 282020

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca