Version 5.4
Bos taurus Gene: KCNK2
Summary
InnateDB Gene IDBG-637791.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK2
Gene Name potassium channel subfamily K member 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004407
Encoded Proteins
IDBP-689825
potassium channel subfamily K member 2
IDBP-689826
potassium channel subfamily K member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082482:
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:69865018-70097416
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005781 ENSBTAP00000005781
ENSBTAT00000043948 ENSBTAP00000041480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015271 outward rectifier potassium channel activity
GO:0022841 potassium ion leak channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0042391 regulation of membrane potential
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000082482
View Gene Order
ENSMUSG00000037624
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75819
TWIK related potassium channel (TREK) pathway
REACT_75897
Tandem pore domain potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
hsa04971
Gastric acid secretion pathway
mmu04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q0VCD1 Q8HY88
UniProt Splice Variant
Entrez Gene 282590
UniGene Bt.12536
RefSeq NM_174686 XM_005217329
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY148474 BC120226 DAAA02043651 DAAA02043652 DAAA02043653 DAAA02043654 DAAA02043655 DAAA02043656 DAAA02043657 DAAA02043658 DAAA02043659 DAAA02043660 DAAA02043661 DAAA02043662 DAAA02043663 DAAA02043664 DAAA02043665
GenPept AAI20227 AAN37591
RNA Seq Atlas 282590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca