InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnk2

Summary

InnateDB Gene

IDBG-208385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnk2

Gene Name

potassium channel, subfamily K, member 2

Synonyms

A430027H14Rik; AI848635; TREK-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037624

Encoded Proteins

IDBP-208387

potassium channel, subfamily K, member 2

IDBP-259234

potassium channel, subfamily K, member 2

IDBP-714522

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082482:
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:189207931-189343832

Strand

Reverse strand

Band

Transcripts

ENSMUST00000079451	ENSMUSP00000078416
ENSMUST00000110920	ENSMUSP00000106545
ENSMUST00000180044	ENSMUSP00000136513

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity
GO:0019870	potassium channel inhibitor activity
GO:0022841	potassium ion leak channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0030322	stabilization of membrane potential
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000082482

View Gene Order

ENSBTAG00000004407

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04971

Gastric acid secretion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75819

TWIK related potassium channel (TREK) pathway

REACT_75897

Tandem pore domain potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

hsa04971

Gastric acid secretion pathway

INOH

PID NCI

Cross-References

SwissProt

P97438

TrEMBL

UniProt Splice Variant

Entrez Gene

16526

UniGene

Mm.33304

RefSeq

NM_001159850 NM_001281847 XM_006497121 NM_010607

OMIM

CCDS

CCDS48480 CCDS48481

HPRD

IMGT

MGI ID

MGI:109366

MGI Symbol

Kcnk2

EMBL

AC121882 AC124527 AY736359 U73488

GenPept

AAC53005 AAV48996

RNA Seq Atlas

16526