InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DNTT

Summary

InnateDB Gene

IDBG-638048.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNTT

Gene Name

DNA nucleotidylexotransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020427

Encoded Proteins

IDBP-690091

DNA nucleotidylexotransferase

IDBP-690095

DNA nucleotidylexotransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107447:
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3\'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:17504714-17540774

Strand

Forward strand

Band

Transcripts

ENSBTAT00000052753	ENSBTAP00000051460
ENSBTAT00000027223	ENSBTAP00000027223

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0003912	DNA nucleotidylexotransferase activity
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity
GO:0046872	metal ion binding

Biological Process

GO:0006259	DNA metabolic process
GO:0006261	DNA-dependent DNA replication
GO:0006304	DNA modification

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000107447

View Gene Order

ENSMUSG00000025014

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa03450

Non-homologous end-joining pathway

mmu04640

Hematopoietic cell lineage pathway

mmu03450

Non-homologous end-joining pathway

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

dnapk_pathway

DNA-PK pathway in nonhomologous end joining

Cross-References

SwissProt

P06526

TrEMBL

UniProt Splice Variant

Entrez Gene

281120

UniGene

Bt.329

RefSeq

NM_177495 XM_005225429 XM_005225430

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114820 M26146 X04122

GenPept

AAA87354 AAI14821 CAA27734

RNA Seq Atlas

281120