InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DNTT

Summary

InnateDB Gene

IDBG-83764.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNTT

Gene Name

deoxynucleotidyltransferase, terminal

Synonyms

TDT

Species

Homo sapiens

Ensembl Gene

ENSG00000107447

Encoded Proteins

IDBP-83766

deoxynucleotidyltransferase, terminal

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3\'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:96304396-96338564

Strand

Forward strand

Band

q24.1

Transcripts

ENST00000371174

ENSP00000360216

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0003912	DNA nucleotidylexotransferase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity
GO:0046872	metal ion binding

Biological Process

GO:0006259	DNA metabolic process
GO:0006261	DNA-dependent DNA replication
GO:0006304	DNA modification

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025014

View Gene Order

ENSBTAG00000020427

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04640

Hematopoietic cell lineage pathway

hsa03450

Non-homologous end-joining pathway

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

dnapk_pathway

DNA-PK pathway in nonhomologous end joining

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.534206

RefSeq

NM_001017520 NM_004088

HUGO

OMIM

CCDS

CCDS7447

HPRD

08925

IMGT

EMBL

GenPept

RNA Seq Atlas