InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RPE65

Summary

InnateDB Gene

IDBG-638059.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPE65

Gene Name

Retinoid isomerohydrolase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020494

Encoded Proteins

IDBP-690121

retinoid isomerohydrolase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116745:
This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:77156911-77178484

Strand

Forward strand

Band

Transcripts

ENSBTAT00000043702

ENSBTAP00000041254

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004744	retinal isomerase activity
GO:0016787	hydrolase activity
GO:0016853	isomerase activity
GO:0046872	metal ion binding
GO:0052884	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity

Biological Process

GO:0001895	retina homeostasis
GO:0007468	regulation of rhodopsin gene expression
GO:0007601	visual perception
GO:0008286	insulin receptor signaling pathway
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0050896	response to stimulus
GO:0050908	detection of light stimulus involved in visual perception
GO:0060041	retina development in camera-type eye
GO:0060042	retina morphogenesis in camera-type eye
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle