Version 5.4
Bos taurus Gene: MIER1
Summary
InnateDB Gene IDBG-638131.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIER1
Gene Name mesoderm induction early response protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005443
Encoded Proteins
IDBP-690183
mesoderm induction early response protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198160:
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). In human, this gene functions as a growth-factor-induced immediate early gene that encodes a transcriptional regulator. Depending on the cellular context, this gene can function as both an activator and repressor of gene transcription. Alternative splicing results in multiple isoforms; some of which contain a nuclear localization signal. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:78663151-78730912
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007161 ENSBTAP00000007161
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0031937 positive regulation of chromatin silencing
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198160
View Gene Order
ENSMUSG00000028522
View Gene Order
Cross-References
SwissProt
TrEMBL Q08DY2
UniProt Splice Variant
Entrez Gene 538742
UniGene Bt.105926 Bt.9611
RefSeq NM_001076913 XM_005204462 XM_005204463 XM_005204464 XM_005204465 XM_005204466 XM_005204467 XM_005204468 XM_005204469 XM_005204470 XM_005204471 XM_005204472 XM_005204473 XM_005204474 XM_005204475 XM_005204476 XM_005204477
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123513 DAAA02008488 DAAA02008489 DAAA02008490
GenPept AAI23514
RNA Seq Atlas 538742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca