InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TXNRD2

Summary

InnateDB Gene

IDBG-638149.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXNRD2

Gene Name

Thioredoxin reductase 2, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000043581

Encoded Proteins

IDBP-690201

thioredoxin reductase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184470:
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. [provided by RefSeq, Jul 2008]
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:74887191-74913312

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000060561

ENSBTAP00000053158

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004791	thioredoxin-disulfide reductase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0007507	heart development
GO:0008033	tRNA processing
GO:0030097	hemopoiesis
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000184470

View Gene Order

ENSMUSG00000075704

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

REACT_188957

Cellular responses to stress pathway

REACT_189141

Detoxification of Reactive Oxygen Species pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00450

Selenocompound metabolism pathway

mmu00240

Pyrimidine metabolism pathway

mmu00450

Selenocompound metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas