Bos taurus Gene: ATP6V1C2
Summary
InnateDB Gene IDBG-638168.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP6V1C2
Gene Name V-type proton ATPase subunit C 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001927
Encoded Proteins
V-type proton ATPase subunit C 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143882:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:86858116-86918106
Strand Reverse strand
Band
Transcripts
ENSBTAT00000032875 ENSBTAP00000032803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0046983 protein dimerization activity
Biological Process
GO:0015991 ATP hydrolysis coupled proton transport
GO:0030177 positive regulation of Wnt signaling pathway
Cellular Component
GO:0005765 lysosomal membrane
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transferrin endocytosis and recycling pathway
Iron uptake and transport pathway
Insulin receptor recycling pathway
Signaling by Insulin receptor pathway
Phagosomal maturation (early endosomal stage) pathway
Transmembrane transport of small molecules pathway
Signal Transduction pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Disease pathway
Signaling by Insulin receptor pathway
Transferrin endocytosis and recycling pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Iron uptake and transport pathway
Transmembrane transport of small molecules pathway
Insulin receptor recycling pathway
Signal Transduction pathway
KEGG
Vibrio cholerae infection pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Oxidative phosphorylation pathway
Collecting duct acid secretion pathway
Phagosome pathway
Oxidative phosphorylation pathway
Phagosome pathway
Collecting duct acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A4IFJ9
UniProt Splice Variant
Entrez Gene 508327
UniGene Bt.48590
RefSeq NM_001083653 XM_005212953
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134614 DAAA02031921
GenPept AAI34615
RNA Seq Atlas 508327