InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ZP2

Summary

InnateDB Gene

IDBG-638186.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZP2

Gene Name

zona pellucida sperm-binding protein 2 precursor

Synonyms

Zp-2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011504

Encoded Proteins

IDBP-690236

zona pellucida sperm-binding protein 2 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103310:
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq, Jul 2008]
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:19228387-19240185

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015289

ENSBTAP00000015289

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032190	acrosin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007339	binding of sperm to zona pellucida
GO:0060468	prevention of polyspermy

Cellular Component

GO:0005576	extracellular region
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0030141	secretory granule
GO:0031012	extracellular matrix

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000103310

View Gene Order

ENSMUSG00000030911

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_163933

Interaction With The Zona Pellucida pathway

REACT_163914

Fertilization pathway

REACT_163848

Reproduction pathway

REACT_199082

Fertilization pathway

REACT_199085

Reproduction pathway

REACT_199072

Interaction With The Zona Pellucida pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E5FYC3 F1MKT2

UniProt Splice Variant

Entrez Gene

280963

UniGene

Bt.7208

RefSeq

NM_173973 XM_005224684 XM_005224689

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02057706 HM631669

GenPept

ADQ47419

RNA Seq Atlas

280963