InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RRM2

Summary

InnateDB Gene

IDBG-638207.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRM2

Gene Name

ribonucleoside-diphosphate reductase subunit M2 isoform 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008216

Encoded Proteins

IDBP-690319

ribonucleotide reductase M2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171848:
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:87466581-87473817

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010802

ENSBTAP00000010802

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515	protein binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0009186	deoxyribonucleoside diphosphate metabolic process
GO:0009262	deoxyribonucleotide metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0051259	protein oligomerization
GO:0051290	protein heterotetramerization
GO:0055114	oxidation-reduction process