Version 5.4
| Bos taurus Gene: LEPR | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-638266.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | LEPR | ||||||||
| Gene Name | leptin receptor | ||||||||
| Synonyms | Ob-R; Ob-RM | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000005910 | ||||||||
| Encoded Proteins |
leptin receptor
leptin receptor
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116678:
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 3:80071689-80147000 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
Leptin pathway
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| REACTOME | |||||||||
| KEGG |
Neuroactive ligand-receptor interaction pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Adipocytokine signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Adipocytokine signaling pathway pathway
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| INOH |
JAK STAT pathway and regulation pathway
JAK STAT pathway and regulation pathway
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| PID NCI |
Signaling events mediated by PTP1B
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Bt.52532 | ||||||||
| RefSeq | NM_001012285 XM_005204450 XM_005204451 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||