InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LEPR

Summary

InnateDB Gene

IDBG-99469.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LEPR

Gene Name

leptin receptor

Synonyms

CD295; LEP-R; LEPRD; OB-R; OBR

Species

Homo sapiens

Ensembl Gene

ENSG00000116678

Encoded Proteins

IDBP-99475

leptin receptor

IDBP-99477

leptin receptor

IDBP-99479

leptin receptor

IDBP-99481

leptin receptor

IDBP-99483

leptin receptor

IDBP-295249

leptin receptor

IDBP-811189

leptin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:65420652-65641559

Strand

Forward strand

Band

p31.3

Transcripts

ENST00000371060	ENSP00000360099
ENST00000371059	ENSP00000360098
ENST00000371058	ENSP00000360097
ENST00000349533	ENSP00000330393
ENST00000344610	ENSP00000340884
ENST00000406510	ENSP00000384025
ENST00000462765
ENST00000471762
ENST00000616738	ENSP00000483390

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004896	cytokine receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007166	cell surface receptor signaling pathway
GO:0007275	multicellular organismal development
GO:0008203	cholesterol metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0045721	negative regulation of gluconeogenesis
GO:0051346	negative regulation of hydrolase activity

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000057722

View Gene Order

ENSBTAG00000005910

Not yet available

Pathways

NETPATH

NetPath_22

Leptin pathway

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

hsa04920

Adipocytokine signaling pathway pathway

INOH

INOH website

JAK STAT pathway and regulation pathway

PID NCI

ptp1bpathway

Signaling events mediated by PTP1B

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.258228 Hs.597358 Hs.723178

RefSeq

NM_001003679 NM_001003680 NM_001198687 NM_001198688 NM_001198689 NM_002303

HUGO

OMIM

CCDS

CCDS30740 CCDS30741 CCDS55604 CCDS631

HPRD

03001

IMGT

EMBL

GenPept

RNA Seq Atlas