Version 5.4
Bos taurus Gene: RNF7
Summary
InnateDB Gene IDBG-638330.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF7
Gene Name RING-box protein 2
Synonyms RNF7
Species Bos taurus
Ensembl Gene ENSBTAG00000002185
Encoded Proteins
IDBP-690395
RING-box protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114125:
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:128214459-128221733
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002831 ENSBTAP00000002831
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019788 NEDD8 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0045116 protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031466 Cul5-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114125
View Gene Order
ENSMUSG00000051234
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q0P5F4
UniProt Splice Variant
Entrez Gene 515595
UniGene
RefSeq NM_001075720 XM_005201868 XM_005201870
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120122 DAAA02002888
GenPept AAI20123
RNA Seq Atlas 515595

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca