Version 5.4
Bos taurus Gene: DOCK7
Summary
InnateDB Gene IDBG-638579.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOCK7
Gene Name dedicator of cytokinesis protein 7
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019877
Encoded Proteins
IDBP-690664
dedicator of cytokinesis 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116641:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:83494253-83658175
Strand Forward strand
Band
Transcripts
ENSBTAT00000026487 ENSBTAP00000026487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007264 small GTPase mediated signal transduction
GO:0007409 axonogenesis
GO:0031175 neuron projection development
GO:0032863 activation of Rac GTPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043473 pigmentation
GO:0045200 establishment of neuroblast polarity
Cellular Component
GO:0008180 COP9 signalosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000116641
View Gene Order
ENSMUSG00000028556
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
Cross-References
SwissProt
TrEMBL F1N3L7
UniProt Splice Variant
Entrez Gene 537464
UniGene Bt.53434
RefSeq NM_001192906
HUGO HGNC:19190
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02008675 DAAA02008676
GenPept
RNA Seq Atlas 537464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca