Version 5.4
Mus musculus Gene: Dock7
Summary
InnateDB Gene IDBG-165723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dock7
Gene Name dedicator of cytokinesis 7
Synonyms 3110056M06Rik; Gm430; m
Species Mus musculus
Ensembl Gene ENSMUSG00000028556
Encoded Proteins
IDBP-165729
dedicator of cytokinesis 7
IDBP-165731
dedicator of cytokinesis 7
IDBP-541549
dedicator of cytokinesis 7
IDBP-534320
dedicator of cytokinesis 7
IDBP-541981
dedicator of cytokinesis 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116641:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:98936665-99120915
Strand Reverse strand
Band C6
Transcripts
ENSMUST00000030286 ENSMUSP00000030286
ENSMUST00000075836 ENSMUSP00000075233
ENSMUST00000124466
ENSMUST00000127417 ENSMUSP00000117797
ENSMUST00000140225
ENSMUST00000124040
ENSMUST00000139152
ENSMUST00000140848
ENSMUST00000150254 ENSMUSP00000114204
ENSMUST00000127946 ENSMUSP00000119103
ENSMUST00000153362
ENSMUST00000131386
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007264 small GTPase mediated signal transduction
GO:0007409 axonogenesis
GO:0031175 neuron projection development
GO:0032863 activation of Rac GTPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043087 regulation of GTPase activity
GO:0043473 pigmentation
GO:0045200 establishment of neuroblast polarity
Cellular Component
GO:0008180 COP9 signalosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116641
View Gene Order
ENSBTAG00000019877
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.260623
RefSeq NM_001290636 NM_026082 XM_006503311 XM_006503312 XM_006503314
OMIM
CCDS CCDS38816 CCDS71425
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca