InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NEK6

Summary

InnateDB Gene

IDBG-638676.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEK6

Gene Name

serine/threonine-protein kinase Nek6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019470

Encoded Proteins

IDBP-690760

serine/threonine-protein kinase Nek6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119408:
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95314593-95400813

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025935

ENSBTAP00000025935

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019894	kinesin binding
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007165	signal transduction
GO:0018105	peptidyl-serine phosphorylation
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0031572	G2 DNA damage checkpoint
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777	protein autophosphorylation