Version 5.4
Homo sapiens Gene: NEK6
Summary
InnateDB Gene IDBG-84700.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEK6
Gene Name NIMA-related kinase 6
Synonyms SID6-1512
Species Homo sapiens
Ensembl Gene ENSG00000119408
Encoded Proteins
IDBP-84702
NIMA (never in mitosis gene a)-related kinase 6
IDBP-84706
NIMA (never in mitosis gene a)-related kinase 6
IDBP-84708
NIMA (never in mitosis gene a)-related kinase 6
IDBP-84710
NIMA (never in mitosis gene a)-related kinase 6
IDBP-242064
NIMA (never in mitosis gene a)-related kinase 6
IDBP-379980
NIMA (never in mitosis gene a)-related kinase 6
IDBP-379984
NIMA (never in mitosis gene a)-related kinase 6
IDBP-379988
NIMA (never in mitosis gene a)-related kinase 6
IDBP-379992
NIMA (never in mitosis gene a)-related kinase 6
IDBP-379994
NIMA (never in mitosis gene a)-related kinase 6
IDBP-379996
NIMA (never in mitosis gene a)-related kinase 6
IDBP-583389
NIMA (never in mitosis gene a)-related kinase 6
IDBP-597097
NIMA (never in mitosis gene a)-related kinase 6
IDBP-584180
NIMA (never in mitosis gene a)-related kinase 6
IDBP-585756
NIMA (never in mitosis gene a)-related kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:124257606-124353307
Strand Forward strand
Band q33.3
Transcripts
ENST00000373603 ENSP00000362705
ENST00000373600 ENSP00000362702
ENST00000320246 ENSP00000319734
ENST00000373596 ENSP00000362698
ENST00000394199 ENSP00000377749
ENST00000444973 ENSP00000389517
ENST00000454453 ENSP00000405215
ENST00000425237 ENSP00000403087
ENST00000423785 ENSP00000399847
ENST00000422297 ENSP00000411401
ENST00000447379 ENSP00000403414
ENST00000540326 ENSP00000441469
ENST00000539416 ENSP00000439651
ENST00000545174 ENSP00000442636
ENST00000546191 ENSP00000441426
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 55 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000910 cytokinesis
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007077 mitotic nuclear envelope disassembly
GO:0007165 signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0018105 peptidyl-serine phosphorylation
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0031572 G2 DNA damage checkpoint
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777 protein autophosphorylation
GO:0051225 spindle assembly
GO:2000772 regulation of cellular senescence
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026749
View Gene Order
ENSBTAG00000019470
Not yet available
Pathways
NETPATH
REACTOME
REACT_160122
Activation of NIMA Kinases NEK9, NEK6, NEK7 pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_160255
Nuclear Envelope Breakdown pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.623608
RefSeq NM_001145001 NM_001166167 NM_001166168 NM_001166169 NM_001166170 NM_001166171 NM_014397 XM_005251664 XM_006716934 XM_006716935
HUGO
OMIM
CCDS CCDS48015 CCDS55338 CCDS55339 CCDS6854
HPRD 05348
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca