InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NR6A1

Summary

InnateDB Gene

IDBG-638695.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR6A1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000040585

Encoded Proteins

IDBP-690784

nuclear receptor subfamily 6, group A, member 1

IDBP-690786

nuclear receptor subfamily 6, group A, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148200:
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:95551663-95586813

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000065207	ENSBTAP00000056004
ENSBTAT00000052227	ENSBTAP00000051129

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007276	gamete generation
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000148200

View Gene Order

ENSMUSG00000063972

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_234105

Nuclear Receptor transcription pathway pathway

REACT_220962

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway

REACT_216222

Transcriptional regulation of pluripotent stem cells pathway

REACT_233572

Gene Expression pathway

REACT_188576

Developmental Biology pathway

REACT_206529

Generic Transcription Pathway pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.32407

RefSeq

XM_002691601 XM_615322

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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