Version 5.4
Mus musculus Gene: Nr6a1
Summary
InnateDB Gene IDBG-166859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr6a1
Gene Name nuclear receptor subfamily 6, group A, member 1
Synonyms 1700113M01Rik; Gcnf; NCNF; RTR
Species Mus musculus
Ensembl Gene ENSMUSG00000063972
Encoded Proteins
IDBP-166861
nuclear receptor subfamily 6, group A, member 1
IDBP-255054
nuclear receptor subfamily 6, group A, member 1
IDBP-534672
nuclear receptor subfamily 6, group A, member 1
IDBP-539332
nuclear receptor subfamily 6, group A, member 1
IDBP-625886
nuclear receptor subfamily 6, group A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148200:
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:38723370-38927688
Strand Reverse strand
Band B
Transcripts
ENSMUST00000076275 ENSMUSP00000075624
ENSMUST00000112877 ENSMUSP00000108498
ENSMUST00000123342
ENSMUST00000128688
ENSMUST00000142113 ENSMUSP00000121234
ENSMUST00000132636
ENSMUST00000142130 ENSMUSP00000115164
ENSMUST00000156301
ENSMUST00000123099
ENSMUST00000168098 ENSMUSP00000126009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007276 gamete generation
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0043401 steroid hormone mediated signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148200
View Gene Order
ENSBTAG00000040585
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_220962
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
REACT_216222
Transcriptional regulation of pluripotent stem cells pathway
REACT_233572
Gene Expression pathway
REACT_188576
Developmental Biology pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.397159 Mm.407428 Mm.439703
RefSeq NM_001159548 NM_001159549 NM_010264 XM_006497708 XM_006497709 XM_006497710
OMIM
CCDS CCDS16012 CCDS50581
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca