Version 5.4
Bos taurus Gene: SOX5
Summary
InnateDB Gene IDBG-638845.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX5
Gene Name transcription factor SOX-5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000022360
Encoded Proteins
IDBP-690953
transcription factor SOX-5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134532:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:86571273-87036285
Strand Forward strand
Band
Transcripts
ENSBTAT00000030260 ENSBTAP00000030245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006366 transcription from RNA polymerase II promoter
GO:0021953 central nervous system neuron differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0045165 cell fate commitment
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048709 oligodendrocyte differentiation
GO:0051216 cartilage development
GO:0060164 regulation of timing of neuron differentiation
GO:0061036 positive regulation of cartilage development
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000741 positive regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134532
View Gene Order
ENSMUSG00000041540
View Gene Order
Cross-References
SwissProt
TrEMBL A4FUB3
UniProt Splice Variant
Entrez Gene 533829
UniGene Bt.32918
RefSeq NM_001083471 XM_005206955
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114658 DAAA02014069 DAAA02014070 DAAA02014071 DAAA02014072 DAAA02014073 DAAA02014074
GenPept AAI14659
RNA Seq Atlas 533829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca