Version 5.4
Bos taurus Gene: BT.39896
Summary
InnateDB Gene IDBG-638899.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.39896
Gene Name complement component C8 alpha chain precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003774
Encoded Proteins
IDBP-691007
complement component C8 alpha chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 12220191
[Homo sapiens] C8A is the alpha subunit of complement factor 8 (C8) and is one of five components that interact to form the cytolytic membrane attack complex (MAC).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157131:
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:89797014-89869019
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004913 ENSBTAP00000004913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
Cellular Component
GO:0005579 membrane attack complex
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000157131
View Gene Order
ENSMUSG00000035031
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8028
Terminal pathway of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
REACT_239142
Innate Immune System pathway
REACT_208792
Complement cascade pathway
REACT_198562
Regulation of Complement cascade pathway
REACT_230745
Immune System pathway
REACT_215211
Terminal pathway of complement pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05020
Prion diseases pathway
hsa05146
Amoebiasis pathway
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05020
Prion diseases pathway
mmu05146
Amoebiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.39896
RefSeq NM_001046285
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca