InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KCNJ8

Summary

InnateDB Gene

IDBG-638954.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ8

Gene Name

ATP-sensitive inward rectifier potassium channel 8

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002551

Encoded Proteins

IDBP-691062

ATP-sensitive inward rectifier potassium channel 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21719711

[Homo sapiens] KCNJ8 is an ATP-sensitive potassium channel that restricts cardiotropic RNA virus replication. (Demonstrated in murine model)

PMID 21719711

[Mus musculus] Kcnj8 is an ATP-sensitive potassium channel that restricts cardiotropic RNA virus replication.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121361:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:88852393-88860007

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003307

ENSBTAP00000003307

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005244	voltage-gated ion channel activity
GO:0015272	ATP-activated inward rectifier potassium channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007507	heart development
GO:0032496	response to lipopolysaccharide
GO:0034765	regulation of ion transmembrane transport
GO:0043330	response to exogenous dsRNA
GO:0051607	defense response to virus
GO:0071805	potassium ion transmembrane transport