InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNJ8

Summary

InnateDB Gene

IDBG-23052.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ8

Gene Name

potassium inwardly-rectifying channel, subfamily J, member 8

Synonyms

KIR6.1; uKATP-1

Species

Homo sapiens

Ensembl Gene

ENSG00000121361

Encoded Proteins

IDBP-23054

potassium inwardly-rectifying channel, subfamily J, member 8

IDBP-583223

potassium inwardly-rectifying channel, subfamily J, member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21719711

KCNJ8 is an ATP-sensitive potassium channel that restricts cardiotropic RNA virus replication. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21719711

[Mus musculus] Kcnj8 is an ATP-sensitive potassium channel that restricts cardiotropic RNA virus replication.

Entrez Gene

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:21764955-21775581

Strand

Reverse strand

Band

p12.1

Transcripts

ENST00000240662	ENSP00000240662
ENST00000537950	ENSP00000440012

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015272	ATP-activated inward rectifier potassium channel activity
GO:0017098	sulfonylurea receptor binding

Biological Process

GO:0001822	kidney development
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0007507	heart development
GO:0009268	response to pH
GO:0010107	potassium ion import
GO:0032496	response to lipopolysaccharide
GO:0034765	regulation of ion transmembrane transport
GO:0042311	vasodilation
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0008282	ATP-sensitive potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030016	myofibril
GO:0042383	sarcolemma
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030247

View Gene Order

ENSBTAG00000002551

Not yet available

Pathways

NETPATH

REACTOME

REACT_75775

ATP sensitive Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75918

Inwardly rectifying K+ channels pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q15842

TrEMBL

A0A024RAV6 F5GY12

UniProt Splice Variant

Entrez Gene

3764

UniGene

Hs.102308 Hs.619408 Hs.741642

RefSeq

NM_004982 XM_005253358

HUGO

HGNC:6269

OMIM

600935

CCDS

CCDS8692

HPRD

IMGT

EMBL

AC010185 BC000544 CH471094 D50312 D50315

GenPept

AAH00544 BAA08851 BAA08852 EAW96450 EAW96451

RNA Seq Atlas

3764