Version 5.4
Bos taurus Gene: SH2D3C
Summary
InnateDB Gene IDBG-639030.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2D3C
Gene Name SH2 domain-containing protein 3C
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015375
Encoded Proteins
IDBP-691150
SH2 domain-containing protein 3C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095370:
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:98435180-98467957
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020433 ENSBTAP00000020433
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000095370
View Gene Order
ENSMUSG00000059013
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A5D7L2
UniProt Splice Variant
Entrez Gene 515820
UniGene Bt.6067
RefSeq NM_001098039 XM_005213255 XM_005213256 XM_005213257 XM_005213258
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140599 DAAA02032156 DAAA02032157 DAAA02032158
GenPept AAI40600
RNA Seq Atlas 515820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca