Version 5.4
Bos taurus Gene: DNM1
Summary
InnateDB Gene IDBG-639193.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNM1
Gene Name Dynamin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011307
Encoded Proteins
IDBP-691339
Dynamin-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106976:
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3\' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:98834514-98877986
Strand Forward strand
Band
Transcripts
ENSBTAT00000032743 ENSBTAP00000032672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
GO:0016787 hydrolase activity
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007032 endosome organization
GO:0008152 metabolic process
GO:0045920 negative regulation of exocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0030117 membrane coat
GO:0042584 chromaffin granule membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000106976
View Gene Order
ENSMUSG00000026825
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223433
Recycling pathway of L1 pathway
REACT_202205
Retrograde neurotrophin signalling pathway
REACT_215526
L1CAM interactions pathway
REACT_213138
Immune System pathway
REACT_203998
Gap junction trafficking pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_214353
Signal Transduction pathway
REACT_202965
Formation of annular gap junctions pathway
REACT_203140
Axon guidance pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_224535
Gap junction trafficking and regulation pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_207066
Signalling by NGF pathway
REACT_214469
Adaptive Immune System pathway
REACT_216714
Innate Immune System pathway
REACT_207353
Gap junction degradation pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_220844
Developmental Biology pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_15
IL3 pathway
REACTOME
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_9411
Gap junction trafficking pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
REACT_239142
Innate Immune System pathway
REACT_224389
Gap junction trafficking and regulation pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_209837
Membrane Trafficking pathway
REACT_220352
Formation of annular gap junctions pathway
REACT_230745
Immune System pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_209040
Gap junction degradation pathway
REACT_261444
Axon guidance pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_217189
Gap junction trafficking pathway
REACT_188257
Signal Transduction pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
hsa04144
Endocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04144
Endocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
cxcr4_pathway
CXCR4-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
erbb1_internalization_pathway
Internalization of ErbB1
ephbfwdpathway
EPHB forward signaling
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
ephrinbrevpathway
Ephrin B reverse signaling
cxcr3pathway
CXCR3-mediated signaling events
notch_pathway
Notch signaling pathway
Cross-References
SwissProt Q08DF4
TrEMBL
UniProt Splice Variant
Entrez Gene 508794
UniGene Bt.40512
RefSeq NM_001076820 XM_005213222 XM_005213223 XM_005213225 XM_005213227
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123778
GenPept AAI23779
RNA Seq Atlas 508794

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca