Version 5.4
Homo sapiens Gene: SERPINI2
Summary
InnateDB Gene IDBG-63921.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINI2
Gene Name serpin peptidase inhibitor, clade I (pancpin), member 2
Synonyms MEPI; PANCPIN; PI14; TSA2004
Species Homo sapiens
Ensembl Gene ENSG00000114204
Encoded Proteins
IDBP-63923
serpin peptidase inhibitor, clade I (pancpin), member 2
IDBP-482122
serpin peptidase inhibitor, clade I (pancpin), member 2
IDBP-476562
serpin peptidase inhibitor, clade I (pancpin), member 2
IDBP-476260
serpin peptidase inhibitor, clade I (pancpin), member 2
IDBP-482262
serpin peptidase inhibitor, clade I (pancpin), member 2
IDBP-485060
serpin peptidase inhibitor, clade I (pancpin), member 2
IDBP-811136
serpin peptidase inhibitor, clade I (pancpin), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:167441789-167479004
Strand Reverse strand
Band q26.1
Transcripts
ENST00000264677 ENSP00000264677
ENST00000476257 ENSP00000420621
ENST00000461846 ENSP00000417692
ENST00000471111 ENSP00000419407
ENST00000495108
ENST00000466903 ENSP00000417752
ENST00000467583 ENSP00000419255
ENST00000465031
ENST00000616363 ENSP00000481699
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006928 cellular component movement
GO:0010951 negative regulation of endopeptidase activity
GO:0030155 regulation of cell adhesion
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034139
View Gene Order
ENSBTAG00000011423
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445555
RefSeq NM_001012303 NM_006217
HUGO
OMIM
CCDS CCDS3200 CCDS75047
HPRD 05722
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca