Version 5.4
Bos taurus Gene: BIN1
Summary
InnateDB Gene IDBG-639275.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BIN1
Gene Name bridging integrator 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019177
Encoded Proteins
IDBP-691561
bridging integrator 1
IDBP-691562
bridging integrator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136717:
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:5350654-5407851
Strand Forward strand
Band
Transcripts
ENSBTAT00000061093 ENSBTAP00000053532
ENSBTAT00000025522 ENSBTAP00000025522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0048156 tau protein binding
Biological Process
GO:0030100 regulation of endocytosis
GO:0042692 muscle cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0060988 lipid tube assembly
GO:0071156 regulation of cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
GO:0060987 lipid tube
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136717
View Gene Order
ENSMUSG00000024381
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
arf6_traffickingpathway
Arf6 trafficking events
Cross-References
SwissProt
TrEMBL Q2KJ23
UniProt Splice Variant
Entrez Gene 614576
UniGene Bt.54746
RefSeq NM_001046541 XM_005202217
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105557 DAAA02003889 DAAA02003890
GenPept AAI05558
RNA Seq Atlas 614576

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca