InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: APOC2

Summary

InnateDB Gene

IDBG-639315.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOC2

Gene Name

Apolipoprotein C-II Apolipoprotein C-II short form

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020558

Encoded Proteins

IDBP-691455

Apolipoprotein C-IIApolipoprotein C-II short form

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000224916:
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011] This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:53057717-53059957

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027393

ENSBTAP00000027393

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008047	enzyme activator activity
GO:0060230	lipoprotein lipase activator activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0006869	lipid transport
GO:0010898	positive regulation of triglyceride catabolic process
GO:0016042	lipid catabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0051006	positive regulation of lipoprotein lipase activity